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(DANRE) ric8b Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6DRJ9 |
| Reactivity | Human, Zebrafish |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Clone/Animal Names | RB48438 |
| Calculated MW | 59522 Da |
| Antigen Region | 444-478 aa |
| Gene ID | 334503 |
|---|---|
| Other Names | Synembryn-B, Protein Ric-8B, Synembryn-like, ric8b, synbl |
| Target/Specificity | This DANRE ric8b antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 444-478 amino acids from the C-terminal region of DANRE ric8b. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (DANRE) ric8b Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ric8b |
|---|---|
| Synonyms | synbl {ECO:0000303|PubMed:15256591} |
| Function | Chaperone that specifically binds and folds nascent G(s) G- alpha proteins (GNAS and GNAL) prior to G protein heterotrimer formation, promoting their association with the plasma membrane. Also acts as a guanine nucleotide exchange factor (GEF) for G(s) proteins by stimulating exchange of bound GDP for free GTP. Acts as an important component for odorant signal transduction by mediating GNAL (G(olf)- alpha) folding, thereby promoting-dependent cAMP accumulation in olfactory sensory neurons. |
| Cellular Location | Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q80XE1}. Note=Localizes to the cell cortex {ECO:0000250|UniProtKB:Q80XE1} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
References
Amsterdam A.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
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